L. Stewart

Modulation of FGF pathway signaling and vascular differentiation using designed oligomeric assemblies

This study designs synthetic oligomeric ligands to modulate FGFR signaling and shows their impact on vascular cell fate decisions.

Design of High Affinity Binders to Convex Protein Target Sites

This paper designs high-affinity proteins that bind to convex protein sites using geometrically matching concave scaffolds, achieving low nanomolar to picomolar affinities.

An artificial intelligence accelerated virtual screening platform for drug discovery

The paper develops RosettaVS, an AI-accelerated virtual screening platform that identifies drug candidates with high binding affinity across two targets, achieving a 14% and 44% hit rate in under seven days.

De novo design of highly selective miniprotein inhibitors of integrins αvβ6 and αvβ8

This paper designs highly selective miniprotein inhibitors for integrins αvβ6 and αvβ8 with picomolar affinity and therapeutic potential in a mouse fibrosis model.

De novo design of high-affinity protein binders to bioactive helical peptides

This paper designs high-affinity protein binders for bioactive helical peptides using deep learning and generative models, achieving picomolar affinity without experimental optimization.

De novo design of modular peptide binding proteins by superhelical matching

This paper introduces a method to design modular peptide binding proteins that bind repeating peptide sequences with high specificity and affinity.

Improving de novo Protein Binder Design with Deep Learning

This paper improves de novo protein binder design by using deep learning models to assess design success rates and computational efficiency.

The role of metal binding in the function of the human salivary antimicrobial peptide histatin-5

This study investigates how histatin-5, a human salivary antimicrobial peptide, interacts with zinc and copper to influence bacterial growth and metal homeostasis in the oral cavity.

Ultrapotent miniproteins targeting the receptor-binding domain protect against SARS-CoV-2 infection and disease in mice

This study evaluates the protective efficacy of modified miniproteins against SARS-CoV-2 in mice, showing reduced viral burden and prevention of lung disease.

Designed proteins assemble antibodies into modular nanocages

The paper designs modular nanocages that assemble antibodies into precise geometries, enhancing signaling and neutralization compared to free antibodies.

Elicitation of broadly protective immunity to influenza by multivalent hemagglutinin nanoparticle vaccines

Nanoparticle immunogens with four seasonal influenza hemagglutinins elicit neutralizing antibodies against both the head and stem, providing broad protection against diverse influenza strains.

Infection via mosquito bite alters Zika virus replication kinetics in rhesus macaques

This study compares ZIKV replication kinetics and tissue distribution in rhesus macaques infected via mosquito bite versus subcutaneous inoculation, finding delayed viral peak and restricted tissue distribution in mosquito-infected animals.