Interleukin-8/CXCR2 signaling regulates therapy-induced plasticity and enhances tumorigenicity in glioblastoma
T. Hasan, S. P. Caragher, J. M. Shireman, C. H. Park, F. Atashi, S. Baisiwala, G. Lee, D. Guo, M. Wu, J. Y. Wang, M. Dey, M. S. Lesniak, C. M. Horbinski, C. D. James, A. U. Ahmed
This study shows IL-8 promotes cellular plasticity and therapeutic resistance in glioblastoma by altering epigenetic marks and enhancing cancer initiating cell properties.
bioRxiv · Nov 16, 2018Cancer Biology