Author

J. M. Shireman

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

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Cancer Biology· 4

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 3 Research Focus:cancer & tumor microenvironment· 3 Approach:experimental assay· 3 Organism:human· 3 Organism:mouse· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1

Frequent Co-Authors

A. U. Ahmed· 4 shared C. D. James· 3 shared C. Park· 3 shared S. Baisiwala· 3 shared F. Atashi· 2 shared G. Lee· 2 shared J. Miska· 2 shared M. S. Lesniak· 2 shared

Activity by Year

2018-2021 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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4 shared papersCancer Biology

A. U. Ahmed

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4 papers

Recent·Most cited

Ribonucleotide Reductase Regulatory Subunit M2 as a Driver of Glioblastoma TMZ-Resistance through Modulation of dNTP Production

E. N. Perrault, J. M. Shireman, E. S. Ali, I. Preddy, P. Lin, C. Park, L. Tomes, A. J. Zolp, S. Budhiraja, S. Baisiwala, C. D. James, I. Ben-Sahra, S. Pott, A. Basu, A. U. Ahmed

This study identifies RRM2 as a driver of TMZ resistance in GBM by modulating dNTP production, showing RRM2 inhibition enhances TMZ efficacy in vivo.

bioRxiv · Nov 23, 2021 · PreprintCancer Biology

De-novo purine biosynthesis is a major driver of chemoresistance in glioblastoma

J. M. Shireman, F. Atashi, G. Lee, E. Ali, M. Saathoff, C. Park, S. Baiswala, J. Miska, M. Lesniak, J. C. David, R. Stupp, P. Kumthekar, C. Horbinski, I. Ben-Sahar, A. U. Ahmed

This study identifies de-novo purine biosynthesis as a driver of chemoresistance in glioblastoma and shows that targeting it with Mycophenolate Mofetil can enhance TMZ efficacy.

Brain · Apr 14, 2021Peer-reviewedCancer Biology

Interleukin-8/CXCR2 signaling regulates therapy-induced plasticity and enhances tumorigenicity in glioblastoma

T. Hasan, S. P. Caragher, J. M. Shireman, C. H. Park, F. Atashi, S. Baisiwala, G. Lee, D. Guo, M. Wu, J. Y. Wang, M. Dey, M. S. Lesniak, C. M. Horbinski, C. D. James, A. U. Ahmed

This study shows IL-8 promotes cellular plasticity and therapeutic resistance in glioblastoma by altering epigenetic marks and enhancing cancer initiating cell properties.

bioRxiv · Nov 16, 2018Cancer Biology

Activation of dopamine receptor 2 (DRD2) prompts transcriptomic and metabolic plasticity in glioblastoma

S. P. Caragher, J. M. Shireman, M. Huang, J. Miska, S. Baisiwala, C. Park, M. Saathoff, L. Warnke, T. Xiao, M. S. Lesniak, C. D. James, H. Meltzer, A. K. Tryba, A. U. Ahmed

This paper shows that dopamine receptor 2 activation in glioblastoma cells increases their growth, stemness, and metabolic activity, suggesting dopamine signaling as a therapeutic target.

bioRxiv · Nov 16, 2018Cancer Biology