S. P. Harris

Myosin-binding protein C forms C-links and stabilizes OFF states of myosin

This study shows that MyBP-CC1C7 domains form C-links and stabilize myosin OFF states, affecting crossbridge kinetics and sarcomere function.

Myofilament Glycation in Diabetes Reduces Contractility by Inhibiting Tropomyosin Movement, is Rescued by cMyBPC Domains

This study identifies myofilament glycation in diabetes as a cause of reduced cardiac contractility, showing that cMyBPC domains can rescue this dysfunction.