Direct Arp2/3-vinculin binding is essential for cell spreading, but only on compliant substrates and in 3D
T. Isogai, K. M. Dean, P. Roudot, Q. Shao, J. D. Cillay, E. S. Welf, M. K. Driscoll, S. P. Royer, N. Mittal, B.-j. Chang, S. J. Han, R. Fiolka, G. Danuser
The paper investigates the role of actin-binding proteins in cell spreading on 2D and 3D substrates, finding that Arp2/3-vinculin binding is critical for 3D spreading but not 2D.
bioRxiv · Sep 4, 2019 · PreprintCell Biology