Author

S. Schiefer

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:drug response / drug discovery· 1 Research Focus:gene regulatory network inference· 1 Approach:genetic perturbation / CRISPR· 1 Research Focus:host-pathogen & immune response· 1 Assay:proteomics· 1

Frequent Co-Authors

B. G. Hale· 2 shared D. Eletto· 1 shared E. Moritz· 1 shared I. Busnadiego· 1 shared J. Börold· 1 shared M. Schwemmle· 1 shared N. K. Mair· 1 shared N. Schmidt· 1 shared

Activity by Year

2021-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersImmunology

B. G. Hale

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2 papers

Recent·Most cited

Proximal protein landscapes of the type I interferon signaling cascade reveal negative regulation by the E3 ubiquitin ligase PJA2

S. Schiefer, B. G. Hale

The paper maps the proximal proteomes of type I IFN signaling components and identifies PJA2 as a negative regulator through ubiquitination of JAK1 and TYK2.

bioRxiv · Oct 4, 2023Immunology

Genome-Wide CRISPR Screening Identifies BRD9 as a Druggable Component of Interferon-Stimulated Gene Expression and Antiviral Activity

J. Börold, D. Eletto, I. Busnadiego, N. K. Mair, E. Moritz, S. Schiefer, N. Schmidt, P. P. Petric, W. W.-L. Wong, M. Schwemmle, B. G. Hale

This study identifies BRD9 as a critical component of IFN signaling and antiviral activity through CRISPR screening, showing its druggability for targeting constitutive ISG expression.

bioRxiv · Feb 4, 2021Immunology