Author

B. G. Hale

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 3 Immunology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:human· 4 Research Focus:drug response / drug discovery· 3 Assay:bulk RNA-seq· 2 Research Focus:host-pathogen & immune response· 2 Research Focus:cell signaling & trafficking· 1 Approach:deep learning· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

I. Busnadiego· 4 shared I. Glas· 2 shared M. O. Pohl· 2 shared S. Schiefer· 2 shared S. Stertz· 2 shared A. Caflisch· 1 shared A. E. Firth· 1 shared A. Hunziker· 1 shared

Activity by Year

2020-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 23 mutual co-author links

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4 shared papersMicrobiology

I. Busnadiego

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Proximal protein landscapes of the type I interferon signaling cascade reveal negative regulation by the E3 ubiquitin ligase PJA2

S. Schiefer, B. G. Hale

The paper maps the proximal proteomes of type I IFN signaling components and identifies PJA2 as a negative regulator through ubiquitination of JAK1 and TYK2.

bioRxiv · Oct 4, 2023Immunology

Combined computational and cellular screening identifies synergistic inhibition of SARS-CoV-2 by lenvatinib and remdesivir

M. O. Pohl, I. Busnadiego, F. Marrafino, L. Wiedmer, A. Hunziker, S. Fernbach, I. Glas, E. V. Moroz-Omori, B. G. Hale, A. Caflisch, S. Stertz

This study combines computational screening and cellular assays to identify lenvatinib and remdesivir as synergistic inhibitors of SARS-CoV-2 replication in Vero-CCL81 cells.

bioRxiv · Mar 19, 2021Microbiology

Manipulation of the unfolded protein response: a pharmacological strategy against coronavirus infection

L. Echavarria-Consuegra, G. M. Cook, I. Busnadiego, C. Lefevre, S. Keep, K. Brown, N. Doyle, G. Dowgier, K. Franaszek, N. A. Moore, S. G. Siddell, E. Bickerton, B. G. Hale, A. E. Firth, I. Brierley, N. Irigoyen

This paper investigates the unfolded protein response (UPR) in coronavirus infection and shows that pharmacological inhibition of the UPR significantly reduces viral replication.

bioRxiv · Mar 19, 2021Microbiology

Genome-Wide CRISPR Screening Identifies BRD9 as a Druggable Component of Interferon-Stimulated Gene Expression and Antiviral Activity

J. Börold, D. Eletto, I. Busnadiego, N. K. Mair, E. Moritz, S. Schiefer, N. Schmidt, P. P. Petric, W. W.-L. Wong, M. Schwemmle, B. G. Hale

This study identifies BRD9 as a critical component of IFN signaling and antiviral activity through CRISPR screening, showing its druggability for targeting constitutive ISG expression.

bioRxiv · Feb 4, 2021Immunology

SARS-CoV-2 Variants Reveal Features Critical for Replication in Primary Human Cells

M. O. Pohl, I. Busnadiego, V. Kufner, I. Glas, U. Karakus, S. Schmutz, M. Zaheri, I. Abela, A. Trkola, M. Huber, S. Stertz, B. G. Hale

This study identifies SARS-CoV-2 variants with distinct replication abilities in human and non-human cells, highlighting cell-specific replication features.

bioRxiv · Oct 22, 2020Microbiology