Author

M. Schwemmle

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 5 Biochemistry· 1 Bioengineering· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 8 Research Focus:host-pathogen & immune response· 7 Organism:human· 4 Organism:mouse· 3 Research Focus:drug response / drug discovery· 2 Assay:proteomics· 2 Research Focus:benchmarking· 1 Research Focus:cell type annotation· 1

Frequent Co-Authors

A. Ohnemus· 3 shared D. Schnepf· 3 shared A. Breithaupt· 2 shared D. Huzly· 2 shared G. Kochs· 2 shared J. Beer· 2 shared K. Ciminski· 2 shared M. Beer· 2 shared

Activity by Year

2020-2023 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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Curved chords = mutual co-authorship

3 shared papersImmunology

A. Ohnemus

Mutual co-authors in cluster

Author profile →

8 papers

Recent·Most cited

IFN-lambda is protective against lethal oral Toxoplasma gondii infection

M. Murillo-Leon, A. M. Bastidas-Quintero, N. S. Endres, D. Schnepf, E. Delgado-Betancourt, A. Ohnemus, G. A. Taylor, M. Schwemmle, P. Staeheli, T. Steinfeldt

This study shows that IFN-lambda protects against lethal oral Toxoplasma gondii infection by enhancing intestinal epithelial and neutrophil responses.

bioRxiv · Feb 24, 2023 · PreprintImmunology

Cold-passaged isolates and bat-swine influenza A chimeric viruses as modified live-attenuated vaccines against influenza A viruses in pigs

A. Graaf, P. P. Petric, J. Sehl-Ewert, D. Henritzi, A. Breithaupt, J. King, A. Pohlmann, F. Deutskens, M. Beer, M. Schwemmle, T. Harder

This study evaluates modified live-attenuated vaccines against swine influenza A viruses using cold-passaged isolates and bat-swine chimeric viruses, finding that chimeric vaccines are safe and induce protective immunity in pigs.

bioRxiv · Jun 20, 2022Microbiology

Impaired immune response drives age-dependent severity of COVID-19

J. Beer, S. Crotta, A. Breithaupt, A. Ohnemus, J. Becker, B. Sachs, L. Kern, M. Llorian, N. Ebert, F. Labroussaa, T. T. N. Tran, B. S. Trueeb, J. Jores, V. Thiel, M. Beer, , D. Schnepf

This study identifies impaired interferon responses as a cause of age-dependent COVID-19 severity and shows that combined IFN-γ and IFN-λ therapy can mitigate disease in aged mice.

bioRxiv · Apr 21, 2022Immunology

A broadly neutralizing biparatopic Nanobody protects mice from lethal challenge with SARS-CoV-2 variants of concern

T. R. Wagner, D. Schnepf, J. Beer, K. Klingel, N. Ruetalo, P. D. Kaiser, D. Junker, M. Sauter, B. Traenkle, D. I. Frecot, M. Becker, N. Schneiderhan-Marra, A. Ohnemus, M. Schwemmle, M. Schindler, U. Rothbauer

This study identifies a biparatopic nanobody that protects mice from lethal SARS-CoV-2 infection and reduces viral load and inflammation.

bioRxiv · Aug 8, 2021 · PreprintBiochemistry

Engineered chimeric T cell receptor fusion construct (TRuC)-expressing T cells prevent translational shutdown in SARS-CoV-2-infected cells

I. Godbole, K. Ciminski, O. S. Yousefi, S. Pathan-Chhatbar, D. Saltukoglu, N. Vesper, P. Salavei, J. Strietz, N. Gensch, M. Reth, M. Schwemmle, W. W. Schamel

Engineered TRuC T cells recognize and kill SARS-CoV-2-infected cells without causing cytotoxicity, rescuing translational shutdown.

bioRxiv · Jun 25, 2021 · PreprintBioengineering

Circulating multimeric immune complexes drive immunopathology in COVID-19

J. Ankerhold, S. Giese, P. Kolb, A. Maul-Pavicic, R. E. Voll, N. Goeppert, K. Ciminski, C. Kreutz, A. Lother, U. Salzer, W. Bildl, T. Welsink, N. Morgenthaler, A. Busse Grawitz, D. Huzly, , V. Falcone

This paper identifies soluble immune complexes as drivers of immunopathology in severe COVID-19 by enhancing FcγRIII activation and forming a vicious cycle of inflammation.

bioRxiv · Jun 25, 2021 · PreprintImmunology

Genome-Wide CRISPR Screening Identifies BRD9 as a Druggable Component of Interferon-Stimulated Gene Expression and Antiviral Activity

J. Börold, D. Eletto, I. Busnadiego, N. K. Mair, E. Moritz, S. Schiefer, N. Schmidt, P. P. Petric, W. W.-L. Wong, M. Schwemmle, B. G. Hale

This study identifies BRD9 as a critical component of IFN signaling and antiviral activity through CRISPR screening, showing its druggability for targeting constitutive ISG expression.

bioRxiv · Feb 4, 2021Immunology

Ex vivo detection of SARS-CoV-2-specific CD8+ T cells: rapid induction, prolonged contraction, and formation of functional memory

I. Schulien, J. Kemming, V. Oberhardt, K. Wild, L. M. Seidel, S. Killmer, Sagar, F. Daul, M. Salvat Lago, A. Decker, H. Luxenburger, B. Binder, D. Bettinger, O. Sogukpinar, S. Rieg, , C. Neumann-Haefelin

This study identifies SARS-CoV-2-specific CD8+ T-cell responses, showing their rapid induction, prolonged contraction, and functional memory formation compared to antibody responses.

bioRxiv · Aug 13, 2020 · PreprintImmunology