Author

S. T. Younger

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2

Signature Assays, Organisms & Methods

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Organism:human· 2 Research Focus:benchmarking· 1 Assay:CRISPR screen· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1 Approach:genetic perturbation / CRISPR· 1 Approach:statistical model· 1

Frequent Co-Authors

A. Conway· 1 shared A. Letai· 1 shared A. Robichaud· 1 shared A. Tsherniak· 1 shared B. Adane· 1 shared B. K. A. Seong· 1 shared C. Larrue· 1 shared C. M. Beaver· 1 shared

Activity by Year

2019-2020 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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1 shared paperCancer Biology

A. Conway

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Author profile →

2 papers

Recent·Most cited

An in vivo CRISPR screening platform for prioritizing therapeutic targets in AML

S. Lin, C. Larrue, B. K. A. Seong, N. V. Dharia, M. Kuljanin, C. Wechsler, G. Kugener, A. Robichaud, A. Conway, T. N. Mashaka, S. Mouche, B. Adane, J. Ryan, J. D. Mancias, S. T. Younger, , K. Stegmaier

This study identifies novel therapeutic targets for AML using an in vivo CRISPR screening platform, revealing SLC5A3 as a metabolic vulnerability and MARCH5 as an apoptosis regulator.

bioRxiv · Dec 28, 2020Cancer Biology

Agreement between two large pan-cancer CRISPR-Cas9 gene dependency datasets

J. M. Dempster, C. Pacini, S. Pantel, F. M. Behan, T. Green, J. Krill-Burger, C. M. Beaver, S. T. Younger, V. Zhivich, H. Najgebauer, F. Allen, E. Goncalves, R. Shepherd, J. G. Doench, K. Yusa, , A. Tsherniak

This study compares two large pan-cancer CRISPR-Cas9 screens, finding high concordance in gene dependencies despite differences in protocols and reagents.

bioRxiv · Jun 4, 2019Cancer Biology