Author

J. D. Mancias

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 6 Cell Biology· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Organism:human· 6 Research Focus:drug response / drug discovery· 5 Approach:experimental assay· 5 Assay:proteomics· 4 Approach:statistical model· 4 Research Focus:chromatin & epigenetic regulation· 3 Assay:bulk RNA-seq· 2 Research Focus:cell signaling & trafficking· 2

Frequent Co-Authors

M. Kuljanin· 4 shared Y. M. Shah· 4 shared N. K. Das· 3 shared A. Robichaud· 2 shared B. Chen· 2 shared B. K. A. Seong· 2 shared C. A. Lyssiotis· 2 shared C. Castillo· 2 shared

Activity by Year

2019-2024 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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4 shared papersCancer Biology

M. Kuljanin

Mutual co-authors in cluster

Author profile →

8 papers

Recent·Most cited

Recharacterization of RSL3 reveals that the selenoproteome is a druggable target in colorectal cancer

S. L. DeAngelo, L. Zhao, S. Dziechciarz, M. Shin, S. Solanki, A. Balia, M. O. El-Derany, C. Castillo, Y. Qin, N. K. Das, H. N. Bell, J. A. Paulo, Y. Zhang, N. J. Rossiter, E. C. McCulla, , Y. M. Shah

This study recharacterizes RSL3 as a broad selenoprotein inhibitor, showing its potential as a therapeutic target for colorectal cancer by inducing ferroptosis.

bioRxiv · Mar 29, 2024 · PreprintCancer Biology

BRD4-mediated epigenetic regulation of endoplasmic reticulum-mitochondria contact sites is governed by the mitochondrial complex III

B. Chen, D. C. Stark, P. V. Jadhav, T. M. Lynn-Nguyen, B. S. Halligan, N. J. Rossiter, N. Sindoni, M. Shin, J. A. Paulo, M. Chang, I. Koo, S. Koshkin, S. Eyunni, P. Ronchi, M. T. Paulsen, , Y. M. Shah

The paper identifies fedratinib as a drug that increases endoplasmic reticulum-mitochondria contact sites by inhibiting BRD4, revealing a novel epigenetic pathway linking ERMCS to cellular metabolism.

bioRxiv · Feb 2, 2024 · PreprintCell Biology

PINK1 supports colorectal cancer growth by regulating the labile iron pool.

B. Chen, N. K. Das, I. Talukdar, R. Singhal, C. Castillo, A. Andren, J. D. Mancias, C. A. Lyssiotis, Y. M. Shah

This study shows PINK1 supports colorectal cancer growth by regulating the labile iron pool through mitophagy and ferritinophagy.

bioRxiv · Sep 27, 2022 · PreprintCancer Biology

Covalent Disruptor of YAP-TEAD Association Suppresses Defective Hippo Signaling

M. Fan, W. Lu, J. Che, N. P. Kwiatkowski, Y. Gao, H.-S. Seo, S. B. Ficarro, P. C. Gokhale, Y. Liu, E. A. Geffken, J. Lakhani, K. Song, M. Kuljanin, W. Ji, J. Jiang, , N. Gray

This paper develops a covalent inhibitor of the YAP-TEAD complex, demonstrating its ability to suppress Hippo signaling defects and inhibit cancer cell growth.

bioRxiv · May 10, 2022Cancer Biology

An in vivo CRISPR screening platform for prioritizing therapeutic targets in AML

S. Lin, C. Larrue, B. K. A. Seong, N. V. Dharia, M. Kuljanin, C. Wechsler, G. Kugener, A. Robichaud, A. Conway, T. N. Mashaka, S. Mouche, B. Adane, J. Ryan, J. D. Mancias, S. T. Younger, , K. Stegmaier

This study identifies novel therapeutic targets for AML using an in vivo CRISPR screening platform, revealing SLC5A3 as a metabolic vulnerability and MARCH5 as an apoptosis regulator.

bioRxiv · Dec 28, 2020Cancer Biology

Intestinal ferritinophagy is regulated by HIF-2 and is essential for systemic iron homeostasis

N. K. Das, A. Sankar, A. J. Schwartz, S. Solanki, X. Ma, S. Parimi, N. Santana-Codina, J. D. Mancias, Y. M. Shah

This study shows HIF-2 regulates intestinal ferritinophagy via NCOA4, which is essential for systemic iron homeostasis.

bioRxiv · Nov 1, 2020 · PreprintPhysiology

Rapid and direct control of target protein levels with VHL-recruiting dTAG molecules

B. Nabet, F. M. Ferguson, B. K. A. Seong, M. Kuljanin, A. L. Leggett, M. L. Mohardt, A. Robichaud, A. S. Conway, D. L. Buckley, J. D. Mancias, J. E. Bradner, K. Stegmaier, N. S. Gray

This paper introduces dTAGV-1, a VHL-recruiting dTAG molecule that rapidly degrades FKBP12F36V-tagged proteins, overcoming limitations of CRBN-recruiting dTAGs and enabling combination degrader studies in cells and mice.

bioRxiv · Mar 13, 2020Cancer Biology

Defining and targeting adaptations to oncogenic KRASG12C inhibition using quantitative temporal proteomics

N. Santana-Codina, A. S. Chandhoke, Q. Yu, B. Małachowska, M. Kuljanin, A. Gikandi, M. Stanczak, S. Gableske, M. P. Jedrychowski, D. A. Scott, A. J. Aguirre, W. Fendler, N. S. Gray, J. D. Mancias

This study uses quantitative temporal proteomics to analyze KRASG12C inhibitor responses in cancer models, identifying effective drug combinations to overcome resistance.

bioRxiv · Sep 14, 2019Cancer Biology