Author

S. Tooze

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 4

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:cell signaling & trafficking· 2 Research Focus:chromatin & epigenetic regulation· 2 Organism:human· 2 Assay:proteomics· 2 Assay:ATAC-seq· 1 Approach:biophysical modeling· 1 Research Focus:protein folding & dynamics· 1

Frequent Co-Authors

T. Nishimura· 2 shared A. Ravussin· 1 shared A. Schreiber· 1 shared C. Davis· 1 shared C. Saito· 1 shared D. Gahlot· 1 shared G. Lazzeri· 1 shared H. B. J. Jefferies· 1 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

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2 shared papersCell Biology

T. Nishimura

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Author profile →

4 papers

Recent·Most cited

Unique Amphipathic α-helix Drives Membrane Insertion and Enzymatic Activity of ATG3

T. Nishimura, G. Lazzeri, N. Mizushima, R. Covino, S. Tooze

The paper identifies an amphipathic α-helix in ATG3 that facilitates membrane insertion and enzymatic activity essential for autophagosome formation.

bioRxiv · Feb 11, 2023 · PreprintCell Biology

Intracellular calcium elevations drive the nucleation of FIP200- and ATG13-containing pre-autophagosomal structures that become omegasomes

M. Smith, P. Schoenfelder, M. Manifava, H. Polson, S. Tooze, L. Roderick, N. Ktistakis

This study shows that sustained intracellular calcium elevations drive the formation of FIP200- and ATG13-containing pre-autophagosomal structures called omegasomes, but not full autophagosomes.

bioRxiv · Nov 2, 2022 · PreprintCell Biology

Cis-membrane association of human ATG8 proteins N-terminus mediates autophagy

S. Tooze, W. Zhang, T. Nishimura, D. Gahlot, C. Saito, C. Davis, H. B. J. Jefferies, A. Schreiber, L. Thukral

This study shows that the N-termini of lipidated ATG8 proteins associate with membranes in cis, which is essential for autophagosome expansion and efficient p62 degradation.

bioRxiv · Jun 10, 2022Cell Biology

The phosphatidylinositol 3-phosphate binding protein SNX4 controls ATG9A recycling and autophagy

H. Stenmark, A. Ravussin, S. Tooze

This study shows that SNX4 is required for ATG9A recycling from endolysosomes to early endosomes, which is essential for autophagic flux.

bioRxiv · Jun 24, 2020Cell Biology