Z. Ahmed

How clinically relevant are prostate cancer cell lines? A comprehensive characterisation and multiomics comparison.

This study evaluates the clinical relevance of prostate cancer cell lines by comparing them to human patient data and multiomics profiles, finding they represent a small fraction of patients and recommending a tailored selection pipeline.

Increasing Chemotherapeutic Efficacy Using pH Modulating and Doxorubicin Releasing Injectable Chitosan-Polyethylene Glycol Hydrogels

This paper develops a hydrogel that delivers doxorubicin and sodium bicarbonate to neutralize tumor acidity and enhance chemotherapy efficacy.

Vascular Smooth Muscle Myosin 2 Filaments Dynamically Assemble and Stabilize During Induced Contractility

This study investigates SMII filament dynamics in vascular smooth muscle cells, showing they are dynamic and stabilize during contraction, with implications for vascular regulation and disease.

Receptor tyrosine kinases regulate signal transduction through a liquid-liquid phase separated state

This study shows that RTKs form liquid-liquid phase-separated states with downstream effectors to enhance signaling fidelity.

Phosphorylation of the M1 muscarinic acetylcholine receptor mediates protection in neurodegenerative disease

This study shows that phosphorylation and arrestin-dependent signaling of the M1 muscarinic receptor provides neuroprotection in prion disease, suggesting potential for developing safer therapies for neurodegenerative diseases.

Regulation of kinase activity by combined action of juxtamembrane and C-terminal regions of receptors

The paper investigates how juxtamembrane and C-terminal regions regulate kinase activity in RTKs, identifying key interactions and mutations linked to disease.

Grb2 binding induces phosphorylation-independent activation of Shp2

This study shows Grb2 binding activates Shp2 independently of phosphorylation, and identifies a peptide that blocks this interaction, reducing Shp2 activity and MAPK signaling.

Intratumor Heterogeneity and Circulating Tumor Cell Clusters

The paper uses simulations to study how tumor growth dynamics and cell turnover affect intratumor heterogeneity and circulating tumor cell cluster diversity, finding that modest changes in growth parameters can significantly increase diversity.