V. Srivastava

Dynamic mechanical sorting biases niche occupancy and lineage outcome during development of bilayered glandular epithelia

The paper shows that mechanical sorting, driven by adhesion and contractility differences, maintains basal-luminal compartmentalization and influences lineage outcomes in glandular epithelia.

Stress relaxing granular bioprinting materials enable complex and uniform organoid self-organization

This paper introduces a tunable granular biomaterial, MAGIC matrix, that enables precise control of initial conditions for tissue growth, leading to improved organoid reproducibility and complexity.

Epidermal IL-33 drives inflammation in necroptosis-induced skin inflammation by recruiting TNF-producing immune cells.

Increasing Chemotherapeutic Efficacy Using pH Modulating and Doxorubicin Releasing Injectable Chitosan-Polyethylene Glycol Hydrogels

This paper develops a hydrogel that delivers doxorubicin and sodium bicarbonate to neutralize tumor acidity and enhance chemotherapy efficacy.

Configurational entropy is an intrinsic driver of tissue structural heterogeneity

The paper uses human mammary organoids to show that configurational entropy drives tissue structural heterogeneity by linking structural parameters to molecular and microenvironmental factors.

Cell wall carbohydrate dynamics during the differentiation of infection structures by the apple scab fungus, Venturia inaequalis

This study investigates cell wall carbohydrate dynamics in Venturia inaequalis during infection structure differentiation, revealing down-regulation of immunogenic carbohydrate biosynthesis genes and chitosan coating of infection structures.

Asynchrony rescues statistically-optimal group decisions from information cascades through emergent leaders

The paper shows that asynchronous decision-making in groups prevents information cascades, allowing early correct decisions to dominate and improve group outcomes.

Microenvironmental engineering improves the self-organization of patterned microvascular networks

This study shows that engineering the microenvironment with fibrillar matrices and removing a serum component improves the self-organization of patterned endothelial cells into perfusable microvascular networks.

Phenotypic and transcriptomic analysis reveals early stress responses in transgenic rice expressing Arabidopsis DREB1a

This study investigates early stress responses in transgenic rice overexpressing Arabidopsis DREB1a, showing improved salinity and drought tolerance with complex transcriptional and metabolic changes.

Computational Investigation of Increased Virulence and Pathogenesis of SARS-CoV-2 Lineage B.1.1.7

This study computationally analyzes mutations in the SARS-CoV-2 B.1.1.7 variant to show increased binding affinity and stability with the hACE-2 receptor, suggesting higher virulence.

Improved binding affinity of the Omicron's spike protein with hACE2 receptor is the key factor behind its increased virulence

This study computes the increased binding affinity of Omicron's spike protein to hACE2 receptor through molecular dynamics and MM-GBSA, identifying key interactions responsible for its enhanced virulence.

Elucidation of sub-cellular H2S metabolism in Solanum lycopersicum L. and its assessment under development and biotic stress

The paper investigates H2S metabolism in tomato under development and biotic stress using in silico analysis of 29 proteins and their sub-cellular localization.

The nuclear effector ArPEC25 from the necrotrophic fungus Ascochyta rabiei targets the chickpea transcription factor CaβLIM1a and negatively modulates lignin biosynthesis for host susceptibility

The Ascochyta rabiei effector ArPEC25 enters the host nucleus and targets the transcription factor CaβLIM1a to manipulate phenylpropanoid pathway for negative modulation of chickpea lignin biosynthesis.

Genotype-dependent and heat-induced grain chalkiness in rice correlates with the expression patterns of starch biosynthesis genes

This study examines how genotype and heat affect grain chalkiness in rice by analyzing the expression patterns of starch biosynthesis genes.

Microbiome-Gut-Brain-Axis communication influences metabolic switch in the mosquito Anopheles culicifacies

This study shows that the gut microbiome influences brain function and metabolic changes in mosquitoes through a microbiome-gut-brain axis.

Recombinase-mediated integration of a multigene cassette in rice leads to stable expression and inheritance of the stacked locus

This paper evaluates Cre-lox recombination for multigene cassette integration in rice, showing stable expression and inheritance of a 5-gene cassette.

Lactoferrin Reverses Methotrexate Driven Epithelial Barrier Defect by Inhibiting TGF-β Mediated Epithelial to Mesenchymal Transition

This study shows lactoferrin reverses methotrexate-induced epithelial barrier defects by inhibiting TGF-β mediated epithelial-mesenchymal transition in intestinal models.

Abrogation of pathogenic attributes in drug resistant Candida auris strains by farnesol

This study shows farnesol reduces biofilm formation and efflux pump activity in drug-resistant Candida auris strains, suggesting it as a potential therapeutic strategy.

Heat-shock inducible CRISPR/Cas9 system generates heritable mutations in rice

This paper develops a heat-shock inducible CRISPR/Cas9 system in rice that enables controlled, heritable mutations with improved precision.

A synergistic transcriptional regulation of olfactory genes derives complex behavioral responses in the mosquito Anopheles culicifacies

This study identifies synergistic regulation of olfactory genes in Anopheles culicifacies that drive complex blood feeding behaviors and predicts novel sensory proteins involved in host seeking.