Author

S. Virdee

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Approach:biophysical modeling· 2 Research Focus:protein folding & dynamics· 2 Assay:proteomics· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:chromatin & epigenetic regulation· 1

Frequent Co-Authors

N. T. Wood· 2 shared P. D. Mabbitt· 2 shared A. J. Fletcher· 1 shared A. Lehner· 1 shared D. B. Grabarczyk· 1 shared D. Carbajo Lopez· 1 shared D. R. Squair· 1 shared E. Roitinger· 1 shared

Activity by Year

2020-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 18 mutual co-author links

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2 shared papersBiochemistry

N. T. Wood

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Author profile →

3 papers

Recent·Most cited

An Atypical E3 Ligase Module in UBR4 Mediates Destabilization of N-degron Substrates

L. Barnsby-Greer, P. D. Mabbitt, M.-A. Dery, D. R. Squair, N. T. Wood, S. Lange, S. Virdee

This study identifies and characterizes a novel E3 ligase module in UBR4, revealing its structural and biochemical specificity for UBE2A and its role in the N-degron pathway.

bioRxiv · May 8, 2023 · PreprintBiochemistry

E3 ubiquitin ligase RNF213 employs a non-canonical zinc finger active site and is allosterically regulated by ATP

J. Ahel, A. J. Fletcher, D. B. Grabarczyk, E. Roitinger, L. Deszcz, A. Lehner, S. Virdee, T. Clausen

This study identifies a non-canonical zinc finger active site in RNF213 and shows its E3 activity depends on ATP binding and adenine nucleotide ratios.

bioRxiv · May 10, 2021Biochemistry

Deubiquitinating Enzyme Amino Acid Profiling Reveals a Class of Ubiquitin Esterases

S. Virdee, V. De Cesare, D. Carbajo Lopez, P. D. Mabbitt, O. Antico, N. T. Wood

This study profiles DUBs for threonine esterase and lysine isopeptidase activity, revealing that the MJD class specifically exhibits ubiquitin esterase activity.

bioRxiv · May 11, 2020Biochemistry