Author

D. B. Grabarczyk

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 4 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Approach:biophysical modeling· 2 Research Focus:cancer & tumor microenvironment· 2 Research Focus:cell signaling & trafficking· 2 Research Focus:chromatin & epigenetic regulation· 2 Organism:human· 2 Research Focus:protein structure prediction· 2 Assay:proteomics· 2

Frequent Co-Authors

T. Clausen· 3 shared G. A. Versteeg· 2 shared L. Deszcz· 2 shared A. J. Fletcher· 1 shared A. Lehner· 1 shared A. Meinhart· 1 shared A. Shulkina· 1 shared A. Winczura· 1 shared

Activity by Year

2019-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 18 mutual co-author links

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3 shared papersBiochemistry

T. Clausen

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Author profile →

5 papers

Recent·Most cited

Guardian ubiquitin E3 ligases target cancer-associated APOBEC3 deaminases for degradation to promote human genome integrity.

I. Schwartz, V. Budroni, M. Meyenberg, H. Hornegger, K. Hacker, S. Schwartz, Z. Hodakova, D. B. Grabarczyk, J. Ehrmann, S. Scinicariello, D. Haselbach, J. Menche, T. Clausen, E. Karagoez, G. A. Versteeg

The paper identifies UBR4, UBR5, and HUWE1 as E3 ligases that degrade cancer-associated APOBEC3 proteins to prevent genome mutagenesis.

bioRxiv · Apr 23, 2024Cell Biology

Structural basis of how the BIRC6/SMAC complex regulates apoptosis and autophagy

J. F. Ehrmann, D. B. Grabarczyk, M. Heinke, L. Deszcz, R. Kurzbauer, O. Hudecz, A. Shulkina, R. Gogova, A. Meinhart, G. A. Versteeg, T. Clausen

The paper determines the cryo-EM structure of BIRC6 and its complex with HTRA2 and SMAC, revealing how SMAC inhibits BIRC6 to regulate apoptosis and autophagy.

bioRxiv · Aug 30, 2022 · PreprintBiochemistry

E3 ubiquitin ligase RNF213 employs a non-canonical zinc finger active site and is allosterically regulated by ATP

J. Ahel, A. J. Fletcher, D. B. Grabarczyk, E. Roitinger, L. Deszcz, A. Lehner, S. Virdee, T. Clausen

This study identifies a non-canonical zinc finger active site in RNF213 and shows its E3 activity depends on ATP binding and adenine nucleotide ratios.

bioRxiv · May 10, 2021Biochemistry

Crystal Structure of the Tof1-Csm3 (Timeless-Tipin) Fork Protection Complex

D. B. Grabarczyk

This study presents the crystal structure of the Tof1-Csm3 complex from Chaetomium thermophilum and characterizes its DNA and peptide-binding properties.

bioRxiv · Jan 24, 2020Biochemistry

A stable leading strand polymerase/clamp loader complex is required for normal and perturbed eukaryotic DNA replication

K. Stokes, A. Winczura, B. Song, G. De Piccoli, D. B. Grabarczyk

This study identifies the role of Ctf18-RFC in DNA replication by showing its interaction with DNA Pol ε and its function in fork protection and checkpoint signaling.

bioRxiv · Oct 17, 2019Biochemistry