Author

P. D. Mabbitt

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 3 Immunology· 1

Signature Assays, Organisms & Methods

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Organism:human· 3 Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Approach:biophysical modeling· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1 Approach:deep learning· 1

Frequent Co-Authors

C. J. Jackson· 2 shared N. T. Wood· 2 shared S. Virdee· 2 shared A. Aderem· 1 shared A. C. Kotze· 1 shared A. Enders· 1 shared A. Harmelin· 1 shared A. M. Buckle· 1 shared

Activity by Year

2019-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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2 shared papersImmunology

C. J. Jackson

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

An Atypical E3 Ligase Module in UBR4 Mediates Destabilization of N-degron Substrates

L. Barnsby-Greer, P. D. Mabbitt, M.-A. Dery, D. R. Squair, N. T. Wood, S. Lange, S. Virdee

This study identifies and characterizes a novel E3 ligase module in UBR4, revealing its structural and biochemical specificity for UBE2A and its role in the N-degron pathway.

bioRxiv · May 8, 2023 · PreprintBiochemistry

Deubiquitinating Enzyme Amino Acid Profiling Reveals a Class of Ubiquitin Esterases

S. Virdee, V. De Cesare, D. Carbajo Lopez, P. D. Mabbitt, O. Antico, N. T. Wood

This study profiles DUBs for threonine esterase and lysine isopeptidase activity, revealing that the MJD class specifically exhibits ubiquitin esterase activity.

bioRxiv · May 11, 2020Biochemistry

Phospho-tuning immunity through Denisovan, modern human, and mouse TNFAIP3 gene variants

N. W. Zammit, O. M. Siggs, P. Gray, K. Horikawa, S. R. Daley, D. B. Langley, D. Cultrone, E. K. Malle, S. N. Walters, J. E. Villanueva, J. Warren, A. Russell, M. J. Cowley, V. Gayevskiy, M. E. Dinger, , M. E. Craig

The paper identifies TNFAIP3 variants in humans, Denisovans, and mice that modulate A20 phosphorylation, revealing a genetic mechanism for balancing immunity and microbial tolerance.

bioRxiv · Mar 27, 2019 · PreprintImmunology

Overcoming insecticide resistance through computational inhibitor design

G. Correy, D. Zaidman, A. Harmelin, S. Carvalho, P. D. Mabbitt, V. Calaora, P. J. James, A. C. Kotze, N. London, C. J. Jackson

The paper designs boronic acid inhibitors to overcome insecticide resistance by targeting carboxylesterases in pests, significantly enhancing insecticide efficacy and reducing usage.

bioRxiv · Jan 24, 2019Biochemistry