Primary cilia mediate diverse kinase inhibitor resistance mechanisms in cancer
A. D. Jenks, S. Vyse, J. P. Wong, D. Keller, T. Burgoyne, A. Shoemark, M. de la Roche, A. Tsalikis, M. Michaelis, J. Cinatl, P. H. Huang, B. E. Tanos
The paper investigates how primary cilia contribute to kinase inhibitor resistance in cancer by altering cilia structure and function, leading to enhanced hedgehog pathway activation and drug resistance.
bioRxiv · Aug 25, 2017Cell Biology