Distinct mechanistic pathways of early tauopathy revealed by MAPT mutations
Martha S. Foiani, Raja Nirujogi, Naoto Watamura, Sumi Bez, Eliona Tsefou, Alessia Santambrogio, Saisha Patel, Davies Hannah, Chris N. Goulbourne, Nayab Fatima, Timothy J.Y. Birkle, Elena Camporesi, Gunnar Brinkmalm, Henrik Zetterberg, Martin Wilkinson, , Karen Duff
This study uses mouse models with tau mutations to show two distinct pathogenic mechanisms in tauopathies, with different progression patterns and responses to amyloid.
bioRxiv · Feb 16, 2026 · PreprintNeuroscience