Eliona Tsefou

Scalable human neuronal models of tauopathy producing endogenous seed-competent 4R tau

This paper develops a scalable human neuronal model of 4R tauopathy with endogenous seed-competent tau for drug discovery.

Distinct mechanistic pathways of early tauopathy revealed by MAPT mutations

This study uses mouse models with tau mutations to show two distinct pathogenic mechanisms in tauopathies, with different progression patterns and responses to amyloid.

Functional analyses and integrated mechanisms of cellular destruction by L-amino acid oxidase

This study investigates how LAAO causes cellular destruction by disrupting multiple organelles, leading to energy failure and cell death.

Tau filaments are tethered within brain extracellular vesicles in Alzheimer's disease

The paper identifies tau filaments within extracellular vesicles from Alzheimer's disease patients using mass spectrometry and cryo-electron microscopy.

Investigation of USP30 inhibition to enhance Parkin-mediated mitophagy: tools and approaches

The paper investigates USP30 inhibition's role in enhancing Parkin-mediated mitophagy using pharmacological and genetic approaches in cellular models.