Author

Sakshi Khosa

Heinrich Heine University Düsseldorf

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Biophysics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:protein folding & dynamics· 2 Assay:protein structure· 2 Organism:yeast· 2 Approach:deep learning· 1 Organism:E. coli· 1 Research Focus:protein structure prediction· 1 Approach:statistical model· 1

Frequent Co-Authors

Lutz SchmittiD· 3 shared Sander H. J. SmitsiD· 3 shared Jens ReinersiD· 2 shared Andreas S. ReichertiD· 1 shared Andrzej HarrisiD· 1 shared Ben Luisi· 1 shared Carol V. RobinsoniD· 1 shared Cigdem GünesiD· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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3 shared papersBiochemistry

Lutz SchmittORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

The multidrug transporter Pdr5 from Saccharomyces cerevisiae is an ergosterol-modulated efflux pump

Lea‐Marie Nentwig, Jakob Helmbrecht, Elise Kaplan, Sakshi Khosa, Haigang Song, Philipp Westhoff, Carol V. Robinson, Sander H. J. Smits, Andrzej Harris, Marten Exterkate, Ben Luisi, Lutz Schmitt

This study reports the cryo-EM structure of Pdr5, showing ergosterol binding and its effect on transporter activity, with implications for fungal drug resistance.

bioRxiv · Oct 30, 2026 · PreprintBiochemistry

In vitro characterization of the baker's yeast deubiquitinase Ubp3

Lars Bostelmann-Arp, Sakshi Khosa, Jens Reiners, Kai Voeltzke, Sander H. J. Smits, Andreas S. Reichert, Lutz Schmitt

This study shows that the catalytic activity of Ubp3, a yeast deubiquitinase, is independent of its interaction partner Bre5, challenging the current model of Bre5-dependent activation.

bioRxiv · Aug 20, 2026 · PreprintBiochemistry

Molecular Insights into CLD Domain Dynamics and Toxin Recruitment of the HlyA E. coli T1SS

Rocco Gentile, Stephan Schott‐Verdugo, Sakshi Khosa, Cigdem Günes, Michele Bonus, Jens Reiners, Sander H. J. Smits, Lutz Schmitt, Holger Gohlke

The paper presents the first complete structural model of the HlyA T1SS using cryo-EM and SAXS, revealing CLD domain dynamics and toxin binding mechanisms.

Journal of Molecular Biology · Oct 11, 2025Peer-reviewedBiophysics