Author

Rocco Gentile

Heinrich Heine University DüsseldorfORCID 0009-0007-1391-4986Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Bioengineering· 1 Biophysics· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:protein folding & dynamics· 2 Approach:statistical model· 2 Organism:bacteria (other)· 1 Organism:C. elegans· 1 Approach:deep learning· 1 Research Focus:drug response / drug discovery· 1 Organism:E. coli· 1

Frequent Co-Authors

Holger GohlkeiD· 3 shared Alexander LehnertiD· 1 shared Astrid WirtziD· 1 shared Cigdem GünesiD· 1 shared Claudia TahirajiD· 1 shared Filip KovačićiD· 1 shared Ifey AlioiD· 1 shared Jens ReinersiD· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 18 mutual co-author links

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3 shared papersBioengineering

Holger GohlkeORCID

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3 papers

Recent·Most cited

BioengineeringTrends in biotechnologyPeer-reviewedOct 1, 2026

Microbial production of the low-caloric sweetener D-allulose from D-glucose by evolutionary engineering

Alexander Lehnert, Rocco Gentile, Claudia Tahiraj…·Michael H. Bott

This paper evolves microbial strains to efficiently produce D-allulose from D-glucose, achieving a 15% yield at 30°C using engineered enzymes and a chassis strain.

2 citations

C. elegansmetagenomics

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Molecular BiologyMicrobiology SpectrumPeer-reviewedJan 21, 2026

A Novel Approach to Combat Pseudomonas aeruginosa: Repurposing Pharmaceuticals for Inhibition of Phospholipase A

Matea Modric, Rocco Gentile, Raphael Moll…·Filip Kovačić

This study identifies three pharmaceuticals that inhibit Pseudomonas aeruginosa phospholipase A, showing they reduce bacterial growth and enhance antibiotic efficacy.

1 citation

bacteria (other)statistical model

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BiophysicsJournal of Molecular BiologyPeer-reviewedOct 11, 2025

Molecular Insights into CLD Domain Dynamics and Toxin Recruitment of the HlyA E. coli T1SS

Rocco Gentile, Stephan Schott‐Verdugo, Sakshi Khosa…·Holger Gohlke

The paper presents the first complete structural model of the HlyA T1SS using cryo-EM and SAXS, revealing CLD domain dynamics and toxin binding mechanisms.

2 citations

E. colistructural biology

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