Engineering physically optimized T cells for increased sampling of complex tumor microenvironments
Hongrong Zhang, Zhongming Chen, Guhan Qian, Christopher D. Zahm, Roberto Alonso‐Matilla, Salena Fischer, Ingunn M. Stromnes, Beau R. Webber, Kevin W. Eliceiri, David J. Odde, Branden S. Moriarity, Paolo P. Provenzano
This study physically optimizes T cells to enhance their ability to sample and engage with pancreatic ductal adenocarcinoma tumor cells, improving therapeutic outcomes.
bioRxiv · Feb 1, 2026 · PreprintBioengineering