Paolo P. Provenzano

This paper develops a base editing platform to efficiently and safely engineer CAR T cells with multiple gene knockouts and insertions.

This study shows that cell migration direction (durotaxis) can be reversed by culturing cells in soft 3D environments, revealing it is influenced by culture conditions rather than being intrinsic.

This study physically optimizes T cells to enhance their ability to sample and engage with pancreatic ductal adenocarcinoma tumor cells, improving therapeutic outcomes.

This paper develops a 3D collagen-based tumor spheroid model to study macrophage-driven ECM remodeling and its impact on cancer cell invasion and malignancy.

The paper uses a biophysical model of the SARS-CoV-2 viral cycle to identify antiviral targets by analyzing parameter sensitivity and pairwise interactions.