Author

Guhan Qian

University of MinnesotaORCID 0000-0002-4993-4512Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Assay:proteomics· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Approach:experimental assay· 1 Approach:genetic perturbation / CRISPR· 1 Organism:human· 1 Organism:mouse· 1

Frequent Co-Authors

Hongrong ZhangiD· 2 shared Ingunn M. StromnesiD· 2 shared Adam L. BurrackiD· 1 shared Alexander K. TsaiiD· 1 shared Ayaka Hulbert· 1 shared Beau R. WebberiD· 1 shared Branden S. MoriarityiD· 1 shared Christopher D. ZahmiD· 1 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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2 shared papersImmunology

Hongrong ZhangORCID

Mutual co-authors in cluster

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2 papers

Recent·Most cited

Abrogating TGFβ signaling in TCR-engineered T cells and enhancing antigen processing by tumor cells promotes sustained therapeutic activity in pancreatic ductal adenocarcinoma

Alexander K. Tsai, Meagan R. Rollins, Madeline A. Ellefson, Zoe C. Schmiechen, Adam L. Burrack, Ayaka Hulbert, Guhan Qian, Hongrong Zhang, Eduardo Cruz-Hinojoza, Jonah Z. Butler, Jason S. Mitchell, Olivia C. Ghirardelli Smith, Stephen D. O’Flanagan, Jenny Krause, Grant H. Hickok, , Ingunn M. Stromnes

This study shows that blocking TGFβ signaling in TCR-engineered T cells and enhancing antigen processing in tumor cells improves their therapeutic effectiveness against pancreatic ductal adenocarcinoma.

Journal for ImmunoTherapy of Cancer · Oct 1, 2026Peer-reviewedImmunology

Engineering physically optimized T cells for increased sampling of complex tumor microenvironments

Hongrong Zhang, Zhongming Chen, Guhan Qian, Christopher D. Zahm, Roberto Alonso‐Matilla, Salena Fischer, Ingunn M. Stromnes, Beau R. Webber, Kevin W. Eliceiri, David J. Odde, Branden S. Moriarity, Paolo P. Provenzano

This study physically optimizes T cells to enhance their ability to sample and engage with pancreatic ductal adenocarcinoma tumor cells, improving therapeutic outcomes.

bioRxiv · Feb 1, 2026 · PreprintBioengineering