SLFN11 restricts escape from telomere crisis to prevent alternative lengthening of telomeres
Sandra Segura‐Bayona, Valérie Borel, Tyler H. Stanage, Marija Maric, Melanie Walter, Rafaela A. Oliveira, Shudong Li, Aurora Irene Idilli, Martina Peritore, Graeme Hewitt, Maarten L. Hekkelman, Daniel M. Snell, Sam T Jones, Chris Cheshire, Areda Elezi, , Simon J. Boulton
This paper identifies SLFN11's role in preventing alternative lengthening of telomeres by eliminating ATRX-deficient cells during telomere crisis, contributing to chemoresistance in cancer.
bioRxiv · Sep 10, 2025 · PreprintMolecular Biology