Maarten L. Hekkelman

SMIM1 drives an alternative iron uptake pathway

This study identifies SMIM1 as a key regulator of an alternative iron uptake pathway through hemoglobin binding and lysosomal iron release, with implications for iron homeostasis and erythropoiesis.

AlphaBridge: tools for the analysis of predicted biomolecular complexes

AlphaBridge evaluates predicted biomolecular complexes using AlphaFold3 confidence metrics, clustering sequence motifs, and visualizing interfaces with 2D diagrams and interactive tools.

SLFN11 restricts escape from telomere crisis to prevent alternative lengthening of telomeres

This paper identifies SLFN11's role in preventing alternative lengthening of telomeres by eliminating ATRX-deficient cells during telomere crisis, contributing to chemoresistance in cancer.

DSSP 4: FAIR annotation of protein secondary structure

DSSP 4 annotates protein secondary structure in a FAIR-compliant manner, introducing left-handed κ-helices and improving interoperability with mmCIF format.

AlphaFill: enriching the AlphaFold models with ligands and co-factors

AlphaFill adds missing ligands and cofactors to AlphaFold protein models using sequence and structure similarity to improve functional interpretation.

3D-Beacons: Decreasing the gap between protein sequences and structures through a federated network of protein structure data resources

3D-Beacons provides a federated network to unify access to protein structure data from multiple sources, enabling comparative analysis of models.

Homology-based loop modelling yields more complete crystallographic protein structures

The paper presents methods to complete missing regions in protein structures using homology information, resulting in 24,962 completed loops in the PDB.