A CRISPR/Cas9 genetically engineered organoid biobank reveals essential host factors for coronaviruses
Joep Beumer, Maarten H. Geurts, Mart Matthias Lamers, Jens Puschhof, Jingshu Zhang, Jelte van der Vaart, Anna Z. Mykytyn, Tim I. Breugem, Samra Riesebosch, Debby Schipper, Petra B. van den Doel, Wim de Lau, Cayetano Pleguezuelos‐Manzano, Georg A. Busslinger, Bart L. Haagmans, Hans C. Clevers
The paper uses CRISPR/Cas9 to generate mutant intestinal organoids and identifies TMPRSS2 as a critical host factor for multiple coronaviruses.
Nature Communications · Sep 17, 2021Peer-reviewedMolecular Biology