Human iPSC-derived prostate organoids with germline BRCA2 mutation undergo tumorigenic transformations
Bipul R. Acharya, George M. Lawless, Pablo Avalos, Prince Anand, Yesai S. Fstkchyan, Shaughn Bell, María Gabriela Otero, Samuel Guillemette, Zachary Myers, Michael J. Workman, William J. Catàlona, Dan Theodorescu, Clive N. Svendsen
This study develops iPSC-derived prostate organoids with and without BRCA2 mutations, showing tumorigenic changes and cancer markers in mutated organoids.
bioRxiv · Aug 26, 2025 · PreprintCancer Biology