Michael J. Workman

This study develops iPSC-derived prostate organoids with and without BRCA2 mutations, showing tumorigenic changes and cancer markers in mutated organoids.

This study evaluates human-derived anti-poly-GA antibodies in cellular and animal models of C9ORF72 disease, showing mixed effects on poly-GA levels and disease progression.

The paper uses single-cell RNA-seq to identify early ALS signatures in iPSC-derived motor neurons across multiple models and platforms.

HiCAGE provides an R package for annotating and visualizing 3C-based genomic data, integrating with RNA-seq and gene ontologies.