Author

Samyuktha Manikandan

Drexel University

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Neuroscience· 2 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Assay:bulk RNA-seq· 2 Research Focus:differential expression· 2 Organism:human· 2 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1 Assay:DNA methylation· 1 Organism:mouse· 1

Frequent Co-Authors

Peter J. GaskilliD· 2 shared Stephanie M. MattiD· 2 shared Yash Agarwal· 2 shared Benjamin C. LiiD· 1 shared Breana ChanneriD· 1 shared Elizabeth A. CrummyiD· 1 shared Elizabeth E. ManningiD· 1 shared Emily A. Nickoloff-Bybel· 1 shared

Activity by Year

2024-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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2 shared papersImmunology

Peter J. GaskillORCID

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3 papers

Recent·Most cited

Epigenetic Regulation of Inflammation by Dopamine in Primary Human Macrophages

Yash Agarwal, Margish D. Ramani, Samyuktha Manikandan, Kimberly A. Bonar, John Montilla, Peter J. Gaskill, Stephanie M. Matt

This study shows dopamine modulates macrophage inflammation through epigenetic changes, including DNA methylation and histone modifications, and highlights individual variability in response.

Frontiers in Immunology · Jun 26, 2026Peer-reviewedImmunology

Dopamine-driven Increase in IL-1β in Myeloid Cells is Mediated by Differential Dopamine Receptor Expression and Exacerbated by HIV

Stephanie M. Matt, Rachel Nolan, Samyuktha Manikandan, Yash Agarwal, Breana Channer, Oluwatofunmi Oteju, Marzieh Daniali, Joanna A. Canagarajah, Teresa LuPone, Krisna Mompho, Kaitlyn Runner, Emily A. Nickoloff-Bybel, Benjamin C. Li, Meng Niu, Johannes C. M. Schlachetzki, , Peter J. Gaskill

This study shows dopamine increases IL-1β in myeloid cells via differential dopamine receptor expression, and this effect is exacerbated by HIV.

bioRxiv · Jun 9, 2024 · PreprintNeuroscience

Sapap3 knockout mice show threat bias under conflict during platform mediated avoidance task: implications for obsessive compulsive disorder

Elizabeth E. Manning, Elizabeth A. Crummy, Zoe LaPalombara, Xiaojun Li, Samyuktha Manikandan, Susanne E. Ahmari

This study examines Sapap3 knockout mice in a platform mediated avoidance task, finding heightened threat bias and altered avoidance behavior compared to controls, suggesting mOFC dysfunction in OCD-related mechanisms.

bioRxiv · Feb 12, 2024 · PreprintNeuroscience