Stephanie M. Matt

Epigenetic Regulation of Inflammation by Dopamine in Primary Human Macrophages

This study shows dopamine modulates macrophage inflammation through epigenetic changes, including DNA methylation and histone modifications, and highlights individual variability in response.

It's Not Rewarding for Mitochondria: Dopamine-Induced Mitochondrial Dysfunction Activates cGAS-STING to Drive IL-6 Secretion in Macrophages

This paper identifies a pathway where dopamine induces mitochondrial dysfunction in macrophages, leading to IL-6 secretion via the cGAS-STING pathway.

High-throughput High Content Quantification of HIV-1 Viral Infectious Output

This paper introduces a high-content imaging assay to quantify HIV-1 infectivity using modified osteosarcoma cells, enabling rapid and consistent evaluation of viral replication dynamics.

Dopamine-driven Increase in IL-1β in Myeloid Cells is Mediated by Differential Dopamine Receptor Expression and Exacerbated by HIV

This study shows dopamine increases IL-1β in myeloid cells via differential dopamine receptor expression, and this effect is exacerbated by HIV.

Functional characterization of the biogenic amine transporter system on human macrophages

This study identifies a DAT-mediated immuno-modulatory mechanism in human macrophages, showing dopamine transport regulates innate immune responses to LPS and is disrupted in disease.