Author

Sara Sepic

Max Planck Institute of Biochemistry

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:drug response / drug discovery· 1 Organism:human· 1 Assay:proteomics· 1

Frequent Co-Authors

Brenda Arlene SchulmaniD· 2 shared Jakub ChrustowicziD· 2 shared Benjamin L. EbertiD· 1 shared Dinah M. Abeja· 1 shared Eleftheria C. PapadopoulouiD· 1 shared Eric S. FischeriD· 1 shared Inchul You· 1 shared Jiale DuiD· 1 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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2 shared papersBiochemistry

Brenda Arlene SchulmanORCID

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2 papers

Recent·Most cited

Multimodal substrate recruitment enables CTLH-MKLN1 E3 ligase to target N-, C-, and internal degrons

Sara Sepic, Karthik V Gottemukkala, Jiale Du, Samuel A. Maiwald, Jakub Chrustowicz, Eleftheria C. Papadopoulou, Susanne von Gronau, Brenda Arlene Schulman

This study reveals how MKLN1's discoidin and Kelch domains recognize diverse degrons through multivalent interactions, enabling substrate recruitment by the CTLH-MKLN1 E3 ligase.

bioRxiv · Sep 16, 2026 · PreprintBiochemistry

Charged Molecular Glue Discovery Enabled by Targeted Degron Display

Zhe Zhuang, Woong Sub Byun, Jakub Chrustowicz, Zuzanna Kozicka, Veronica L. Li, Dinah M. Abeja, Katherine A. Donovan, Sara Sepic, Inchul You, Mikolaj Michal Slabicki, Eric S. Fischer, Stephen M. Hinshaw, Benjamin L. Ebert, Brenda Arlene Schulman, Nathanael S. Gray

The paper discovers a charged molecular glue, c-Glue, through targeted degron display, enabling the development of Molecular Glue Degraders (MGDs) for protein degradation.

Nature Chemical Biology · Apr 6, 2026Peer-reviewedBiochemistry