Drug-controlled CAR-T cells through the regulation of cell-cell interactions
Leo Scheller, Greta Maria Paola Giordano Attianese, Rocío Castellanos-Rueda, Raphaël B. Di Roberto, Markus Barden, Melanie M. Triboulet, Morteza Hafezi, Sarah Ash, Sailan Shui, Elisabetta Cribioli, Patrick Reichenbach, Jimmy Maillard, Anthony Marchand, Sandrine Georgeon, Benita Wolf, , Melita B. Irving
This paper develops DROP-CARs, drug-regulated CAR-T cells that control cell-cell interactions using small-molecule switches, showing in vitro and in vivo functionality.
Nature Chemical Biology · Feb 19, 2026Peer-reviewedSynthetic Biology