Hinrich Abken

Multicenter preclinical validation of next-generation CAR T cells: a strategy for harmonization, reproducibility, and its feasibility in clinical translation

This paper validates a multicenter preclinical strategy for CAR T cells, demonstrating its feasibility in confirming CCR8 overexpression benefits across multiple centers.

Drug-controlled CAR-T cells through the regulation of cell-cell interactions

This paper develops DROP-CARs, drug-regulated CAR-T cells that control cell-cell interactions using small-molecule switches, showing in vitro and in vivo functionality.

Dextran-based T-cell expansion nanoparticles for manufacturing CAR T cells with augmented efficacy

This paper introduces T-Expand, a dextran-based nanoparticle system for T cell expansion that enhances CAR T cell efficacy and reduces manufacturing complexity.

Development of antigen-dextramers for detection and evaluation of CAR T cells

This paper develops antigen-dextramers to stain and functionally assess CAR T cells, showing they enable both detection and activation analysis with adjustable antigen density.