The transcription factor TCF21 is necessary for adoption of cell fates by Foxd1+ stromal progenitors during kidney development
Gal Finer, George Yacu, Mohammad Daud Khan, Yalu Zhou, Gaurav T. Gadhvi, Sarah E. Ward, Mohammed E. Sayed, R. Ariel Gomez, Maria Luisa S. Sequeira-Lόpez, Joo-Seop Park, Hee‐Woong Lim, Susan E. Quaggin, Deborah R. Winter
This study uses scRNA-seq to show that Tcf21 is essential for Foxd1+ stromal progenitor differentiation during kidney development, with loss of Tcf21 causing stromal subpopulation depletion and emergence of Emcn-expressing cells.
American Journal of Physiology-Renal Physiology · Feb 3, 2026Peer-reviewedDevelopmental Biology