Gaurav T. Gadhvi

LIGER2 improves single-cell data integration by enhancing scalability and efficiency while preserving biological variation.

The paper identifies four distinct synovial macrophage populations in RA models and shows conserved inflammatory responses across conditions.

CytoSignal detects and quantifies ligand-receptor signaling interactions at cellular resolution from spatial transcriptomic data, enabling spatial gradient analysis and temporal dynamics prediction.

This study uses scRNA-seq to show that Tcf21 is essential for Foxd1+ stromal progenitor differentiation during kidney development, with loss of Tcf21 causing stromal subpopulation depletion and emergence of Emcn-expressing cells.

The paper examines alveolar T cell responses in SARS-CoV-2 pneumonia patients, finding that early interferon signaling and targeting of structural proteins correlate with better clinical outcomes.

This study identifies distinct TNF-dependent aging signatures in monocyte subpopulations, showing that aging affects their transcriptional regulation differently.

This study identifies three monocyte transcriptional subgroups in SSc patients that correlate with disease activity, particularly lung function.