The accumulation of N6-methyl-2-deoxyadenosine in DNA drives activity-induced gene expression and is required for the extinction of conditioned fear
Xiang Li, Qiongyi Zhao, Wei Wei, Quan Lin, Christophe Magnan, Michael R. Emami, Luis E. Wearick da Silva, Thiago Wendt Viola, Paul Robert Marshall, Jaiyu Yin, Sachithrani U. Madugalle, Sarah Nainar, Cathrine Broberg Vågbø, Laura Jane Leighton, Esmi Lau Zajaczkowski, , Timothy William Bredy
This study shows that m6dA accumulation in DNA of prefrontal cortical neurons is linked to fear extinction learning and gene expression.
bioRxiv · Jul 25, 2018 · PreprintNeuroscience