The Onset of Breathing at Birth Switches Off Regenerative Capacity
Xuan Song, Xinyi Cai, Shane Hegarty, Davide Speri, Masahiro Yasuda, Ryan Donahue, Joanna Stanicka, Ting Yan, Susu Mao, Sarah Yang, Jiawen Chen, Junjie Zhu, James Kiraly, Cheng-Hao Chien, Evgenii Kegeles, , Zhigang He
The paper shows that breathing at birth triggers CO2 exhalation, which reduces mTOR activity and limits regenerative capacity in CNS neurons and other tissues, but this effect is reversible with CO2 inhalation or Snrk deletion.
bioRxiv · Oct 11, 2026 · PreprintNeuroscience