Ryan Donahue

The paper shows that breathing at birth triggers CO2 exhalation, which reduces mTOR activity and limits regenerative capacity in CNS neurons and other tissues, but this effect is reversible with CO2 inhalation or Snrk deletion.

This study shows that OPTN dysfunction leads to neuroinflammation and RGC death in glaucoma, independent of IOP, and identifies OPTN-NPY signaling as a potential therapeutic target.

This paper develops a biologically inspired microbead platform for inducing chronic ocular hypertension in mice, leading to retinal ganglion cell loss and visual pathway impairment.

The paper identifies four ATF/CEBP transcription factors that drive injury-induced neurodegeneration of retinal ganglion cells and shows their role in glaucoma.