A transgene harboring the human Glucose Transporter1 (GLUT1) gene locus ameliorates disease in GLUT1 deficiency syndrome model mice.
Maoxue Tang, Sasa Teng, Ashley Y. Kim, Yueqing Peng, Umrao R. Monani
This study shows that transgenic expression of the human GLUT1 gene in a mouse model of GLUT1 deficiency syndrome improves brain glucose levels, motor function, and seizure frequency.
bioRxiv · Apr 5, 2025 · PreprintNeuroscience