Author

Sean M. Vigeant

Harvard University

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 1

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Approach:experimental assay· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1

Frequent Co-Authors

Charles XuiD· 1 shared Eddy SaadiD· 1 shared Hairong WeiiD· 1 shared Hilina B. WoldemichaeliD· 1 shared Jason Robert PitarresiiD· 1 shared Jing LuiD· 1 shared Kei EnomotoiD· 1 shared Laura A. StranskyiD· 1 shared

Activity by Year

2025-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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1 shared paperCancer Biology

Charles XuORCID

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1 paper

Recent·Most cited

HIF2-driven PTHrP Causes Cachexia and Hypercalcemia in Kidney Cancer: Treatment with HIF2 Inhibitors

Muhannad Abu‐Remaileh, Laura A. Stransky, Nikita Bhalerao, Nitin H. Shirole, Qinqin Jiang, Eddy Saad, Marc Machaalani, Sean M. Vigeant, Hilina B. Woldemichael, Charles Xu, Jing Lu, Hairong Wei, Zhihong Liu, William Y. Sun, Kei Enomoto, , William G. Kaelin

This study identifies HIF2-driven PTHrP as a cause of cachexia and hypercalcemia in kidney cancer and shows that HIF2 inhibitors can alleviate these symptoms.

Nature Medicine · Nov 28, 2025Peer-reviewedCancer Biology