Author

Marc Machaalani

Harvard UniversityORCID 0000-0002-6708-9922Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:host-pathogen & immune response· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Assay:clinical cohort / trial· 1 Research Focus:differential expression· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Toni K. ChoueiriiD· 2 shared Ailin Han· 1 shared Alexander L Gusev· 1 shared Amin H. NassariD· 1 shared Athreya S RangavajhulaiD· 1 shared Charles XuiD· 1 shared Chun J. Ye· 1 shared Claire Quattropani· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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2 shared papersImmunology

Toni K. ChoueiriORCID

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2 papers

Recent·Most cited

DPP9-mediated inflammasome repression protects against checkpoint inhibitor lung toxicity

J. Richard Brewer, Ailin Han, Amin H. Nassar, Elias Bou Farhat, Holly N. Blackburn, Tianli Xiao, Haris Mirza, Walter K. Mowel, Esen Sefik, Saskia Hartner, Michael Chiorazzi, Takeshi Ito, Min Hee Oh, Matthew Z. Madden, Athreya S Rangavajhula, , Richard Anthony Flavell

The paper identifies DPP9 as a genetic susceptibility gene for checkpoint inhibitor pneumonitis and shows IL-18 blockade could be a therapeutic strategy.

bioRxiv · Jul 3, 2026 · PreprintImmunology

HIF2-driven PTHrP Causes Cachexia and Hypercalcemia in Kidney Cancer: Treatment with HIF2 Inhibitors

Muhannad Abu‐Remaileh, Laura A. Stransky, Nikita Bhalerao, Nitin H. Shirole, Qinqin Jiang, Eddy Saad, Marc Machaalani, Sean M. Vigeant, Hilina B. Woldemichael, Charles Xu, Jing Lu, Hairong Wei, Zhihong Liu, William Y. Sun, Kei Enomoto, , William G. Kaelin

This study identifies HIF2-driven PTHrP as a cause of cachexia and hypercalcemia in kidney cancer and shows that HIF2 inhibitors can alleviate these symptoms.

Nature Medicine · Nov 28, 2025Peer-reviewedCancer Biology