Simran Singh

Mitigation of Parkinson's Disease Pathology in C. elegans by Marine Bacterium Kocuria rhizophila via Ferroptosis Suppression

This study shows that the marine bacterium Kocuria rhizophila CDMP12 reduces Parkinson's disease pathology in C. elegans by suppressing ferroptosis and alpha-synuclein aggregation.

Myeloid Gi signaling acts as a weight-independent immunometabolic switch controlling systemic insulin sensitivity

This paper identifies myeloid Gi signaling as a weight-independent immunometabolic switch that regulates systemic insulin sensitivity through opposing cytokine programs.

Unraveling the Core: Hub Genes Bridging Familial and Sporadic Parkinson's Disease

This study identifies twelve hub genes involved in membrane trafficking and vesicle-mediated transport that are dysregulated in both familial and idiopathic Parkinson's disease and show potential as therapeutic targets.

Acute activation of Gq-signaling in islet macrophages inhibits β-cell insulin secretion through AMPK-sphingolipid axis

This study shows that activating Gq-signaling in islet macrophages impairs β-cell insulin secretion via the AMPK-sphingolipid axis, revealing a new immune-endocrine communication mechanism.

A Temporal Single-Cell Multi-Omics Atlas of Murine Pancreatic Islet Remodeling During Hyperglycaemia Progression

This study maps dynamic changes in murine pancreatic islet cell composition and transcriptional states during hyperglycaemia progression using single-cell multi-omics data.

Faster amylin aggregation on fibrillar collagen hastens diabetic progression through β cell death and loss of function

This study shows that amylin aggregates faster on fibrillar collagen, leading to β-cell death and dysfunction, which accelerates diabetic progression.