Author

Seiichi Sugino

Kyoto University

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioinformatics· 1 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Organism:human· 2 Research Focus:cancer & tumor microenvironment· 1 Assay:CRISPR screen· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1 Assay:scRNA-seq· 1 Approach:statistical model· 1

Frequent Co-Authors

Kosuke YusaiD· 2 shared Yusuke TarumotoiD· 2 shared Akio Mizutani· 1 shared Atsushi MochizukiiD· 1 shared Daisuke MorishitaiD· 1 shared Fumi Wagai· 1 shared Hidekazu TokuharaiD· 1 shared Hiroko YamakawaiD· 1 shared

Activity by Year

2023-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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2 shared papersCancer Biology

Kosuke YusaORCID

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2 papers

Recent·Most cited

CDK12/13 inhibitor, CTX-439, suppresses tumor growth and potentiates BCL-2 family blockade

Hiroko Yamakawa, Raghda Khatab, Akio Mizutani, Shunsuke Ebara, Takaharu Hirayama, Sunao Tanaka, Yusuke Tarumoto, Midori Sugiyama, Seiichi Sugino, Mariko Takano, Hidekazu Tokuhara, Toshio Tanaka, Hiroshi Banno, Yasuyoshi Arikawa, Yukiko Fukui, , Kosuke Yusa

This study develops CTX-439, a CDK12/13 inhibitor, showing anti-tumor effects and resistance mechanisms, and proposes combining it with BCL-2 family inhibitors for cancer treatment.

bioRxiv · Feb 20, 2026 · PreprintCancer Biology

Inference of gene regulatory networks using time-series single-cell RNA-seq data with CRISPR perturbations

Masato Ishikawa, Seiichi Sugino, Yoshie Masuda, Yusuke Tarumoto, Yusuke Seto, Nobuko Taniyama, Fumi Wagai, Yuhei Yamauchi, Yasuhiro Kojima, Hisanori Kiryu, Kosuke Yusa, Mototsugu Eiraku, Atsushi Mochizuki

This paper introduces RENGE, a method for inferring gene regulatory networks from time-series scCRISPR data, which outperforms existing methods and produces GRNs consistent with known databases.

bioRxiv · Aug 23, 2023 · PreprintBioinformatics