Regulation of virion production by the ORF8 signal peptide across SARS-CoV-2 variants
Mir Mubashir Khalid, Irene P. Chen, Frank W. Soveg, Taha Y. Taha, Takako Tabata, Rahul Suryawanshi, Abdullah M. Syed, Alison Ciling, Maria McCavitt-Malvido, Ursula Schulze‐Gahmen, Jennifer M. Hayashi, Ik-Jung Kim, Seiw Wai Fong, Jyoti Batra, G. Renuka Kumar, , Mélanie Ott
This study shows ORF8 suppresses viral particle production by interacting with Spike and causing Golgi fragmentation, supporting evolutionary pressure to delete ORF8 in SARS-CoV-2 variants.
bioRxiv · Mar 5, 2024 · PreprintMicrobiology