Author
Gladstone InstitutesORCID 0000-0001-9861-7647Unclaimed ORCID profile · follow to get notified of new preprints
4 papers
Recent·Most cited
Edel M. McCrea, Neoklis Makrides, Takako Tabata…·Laura Donatella Attardi
This study shows that Ptpn14 deficiency in mice causes female-specific Hippo pathway defects, including corneal lesions, uterine defects, and organ abnormalities, with conserved roles in humans.
Mir Mubashir Khalid, Irene P. Chen, Frank W. Soveg…·Mélanie Ott
This study shows ORF8 suppresses viral particle production by interacting with Spike and causing Golgi fragmentation, supporting evolutionary pressure to delete ORF8 in SARS-CoV-2 variants.
Bingchen Yu, Shanshan Li, Takako Tabata…·Lei Wang
This paper develops covalent nanobodies using a PERx mechanism to neutralize SARS-CoV-2 and variants with greatly increased potency.
Irene P. Chen, James E. Longbotham, Sarah McMahon…·Mélanie Ott
The paper shows that BET proteins are antiviral factors against SARS-CoV-2, and the viral E protein neutralizes BET-mediated post-entry antiviral effects.