Eric M. Verdin

This study shows curcumin and sulforaphane improve mobility in aging C. elegans through distinct transcriptional mechanisms, with their combination enhancing detoxification and reducing immune gene expression.

This paper develops a proteomic workflow to confidently identify and quantify lysine methylmalonylation in mouse brain tissue, revealing its regulation by SIRT5 and its role in myelin stability.

The paper develops an EEG-based brain age clock using machine learning to predict chronological age and assess brain aging, showing a decrease in brain age with intervention.

This study uses single-cell transcriptomics to analyze immune aging, finding that acute COVID and HIV+ART both increase naive CD8 T cell transcriptomic age.

The paper identifies age-associated Th2-like CD8 memory T cells in human blood and links their accumulation to health conditions like asthma and diabetes.

The paper identifies and characterizes SA-βGal-high naive T cells that exhibit senescent-like features but retain proliferative capacity and cytotoxic properties, linking lysosomal-autophagic dysfunction to immune aging and inflammaging.

The paper introduces iprm-PASEF, a targeted MSI method, to identify and quantify metabolites and lipids in CD38 knockout mice, showing increased NAD+ and decreased ADPR.

This study identifies high stoichiometry lysine succinylation sites in mouse liver, showing their functional role in urea cycle regulation and ammonia metabolism through SIRT5.

This study shows ORF8 suppresses viral particle production by interacting with Spike and causing Golgi fragmentation, supporting evolutionary pressure to delete ORF8 in SARS-CoV-2 variants.

This study shows that sleep disruption in mice increases cellular senescence in visceral adipose tissue, leading to oxidative stress and DNA damage, which may accelerate aging and age-related diseases.

This study shows CD38 loss increases ovarian NAD+ levels and fecundity in young mice but not in older mice.

The paper develops a novel epigenetic clock, IntrinClock, that measures age-related changes independent of immune cell composition, showing age reversal in reprogramming.

The paper identifies SIRT5 and KAT2A as regulators of histone malonylation, showing its role in ribosomal gene expression and age-related changes in mouse brains.

The paper shows that small-molecule ketone esters reduce epileptiform discharges and improve cognition in an Alzheimer's disease mouse model.

The paper identifies mt-ELP3 as a mitochondrial tRNA modifying enzyme that protects mt-tRNAs from degradation and enhances mitochondrial translation and OXPHOS complex expression.

The paper investigates how excess dietary sugar and fat affect liver mitochondria protein acetylation and succinylation in mice through multi-omic profiling.

This study shows that a ketogenic diet and beta-hydroxybutyrate reduce epileptiform spikes, improve memory, and increase survival in Alzheimer's mouse models.