Author

Irene P. Chen

Gladstone InstitutesORCID 0000-0002-5766-9253Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Microbiology· 2 Molecular Biology· 1 Synthetic Biology· 1 Systems Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Organism:human· 4 Research Focus:host-pathogen & immune response· 2 Assay:proteomics· 2 Research Focus:benchmarking· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

Mélanie OttiD· 5 shared Nevan J. KroganiD· 4 shared Taha Y. TahaiD· 4 shared Jennifer M. HayashiiD· 3 shared Amy DialloiD· 2 shared Chengjin YeiD· 2 shared Danielle L. SwaneyiD· 2 shared Frank W. SovegiD· 2 shared

Activity by Year

2022-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 42 mutual co-author links

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5 shared papersMicrobiology

Mélanie OttORCID

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Author profile →

5 papers

Recent·Most cited

Systems BiologyCell Host & MicrobePeer-reviewedMay 14, 2026

Coronavirus protein interaction mapping in bat and human cells identifies molecular and genetic switches for immune evasion and replication

Jyoti Batra, Magdalena Rutkowska, Yuan Zhou…·Nevan J. Krogan

4 citationstop 1%

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MicrobiologyPLoS PathogensPeer-reviewedMar 31, 2025

Enhanced RNA replication and pathogenesis in recent SARS-CoV-2 variants harboring the L260F mutation in NSP6

Taha Y. Taha, Shahrzad Ezzatpour, Jennifer M. Hayashi…·Mélanie Ott

This study identifies the L260F mutation in NSP6 as enhancing RNA replication and pathogenesis in recent SARS-CoV-2 variants, independent of Spike function.

12 citationstop 2%

humanwhole-genome sequencing

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MicrobiologybioRxivPreprintMar 5, 2024

Regulation of virion production by the ORF8 signal peptide across SARS-CoV-2 variants

Mir Mubashir Khalid, Irene P. Chen, Frank W. Soveg…·Mélanie Ott

This study shows ORF8 suppresses viral particle production by interacting with Spike and causing Golgi fragmentation, supporting evolutionary pressure to delete ORF8 in SARS-CoV-2 variants.

12 citations

humanproteomics

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Synthetic BiologybioRxivPreprintJan 12, 2024

De novo-designed minibinders expand the synthetic biology sensing repertoire

Zara Y. Weinberg, Sarah S. Soliman, Matthew S. Kim…·Hana El‐Samad

This study demonstrates that de novo-designed minibinders can be adapted to various cell engineering tools, improving antigen detection and cytotoxicity compared to antibody-based systems.

1 citation

protein sequenceexperimental assay

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Molecular BiologyCell ReportsPeer-reviewedJun 27, 2022

Viral E Protein Neutralizes BET Protein-Mediated Post-Entry Antagonism of SARS-CoV-2

Irene P. Chen, James E. Longbotham, Sarah McMahon…·Mélanie Ott

The paper shows that BET proteins are antiviral factors against SARS-CoV-2, and the viral E protein neutralizes BET-mediated post-entry antiviral effects.

28 citations

humanstatistical model

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