JAK1/2 Inhibition Delays Cachexia and Improves Survival through Increased Food Intake
Ezequiel Dantas, Anirudh Murthy, Jeshua Kim, Tanvir Ahmed, Mujmmail Ahmed, Tiffany Perrier, Shakti Ramsamooj, Isaac Nathoo, Lucas Kniess Debarba, André Lima Queiroz, Shiri Li, Baran A. Ersoy, Miriam Ferrer, Ido Goldstein, Jonathan Gao, , Marcus DaSilva Goncalves
This study shows that JAK1/2 inhibition with ruxolitinib improves survival and body weight in lung cancer models by increasing food intake and restoring metabolic function.
bioRxiv · Oct 21, 2025 · PreprintCancer Biology