Lucas Kniess Debarba

Intestinal fructose metabolism drives unsaturated fat absorption and synergizes with GLP-1 receptor agonism to promote weight loss

This study shows that inhibiting fructose metabolism via KHKi reduces weight gain and enhances weight loss when combined with GLP-1 receptor agonism in mice.

JAK1/2 Inhibition Delays Cachexia and Improves Survival through Increased Food Intake

This study shows that JAK1/2 inhibition with ruxolitinib improves survival and body weight in lung cancer models by increasing food intake and restoring metabolic function.

Hypothalamic Sex-Specific Metabolic Shift by Canagliflozin during Aging

This study shows Canagliflozin improves metabolic control in aged male mice but not females, with sex-specific effects on hypothalamic gene expression and metabolic pathways.

Microglial NF-κB Signaling Deficiency Protects Against Metabolic Disruptions Caused by Volatile Organic Compound via Modulating the Hypothalamic Transcriptome

Prenatal benzene exposure alters offspring hypothalamic development predisposing to metabolic disease in later life

This study shows that prenatal benzene exposure alters hypothalamic development in male offspring, leading to metabolic dysregulation and increased susceptibility to metabolic disease later in life.

Growth hormone receptor (GHR) in AgRP neurons regulatesthermogenesis in aged mice in a sex-specific manner

This study shows that GHR in AgRP neurons affects thermogenesis in aged mice, with sex-specific differences in body temperature and BAT gene expression.

Neuroprotective effects of Canagliflozin: lessons from aged genetically diverse UM-HET3 mice.

This study shows that Canagliflozin improves central insulin sensitivity and reduces neuroinflammation in aged male mice but not females, suggesting sex-specific neuroprotective effects.

Growth hormone receptor (GHR)-expressing neurons in the hypothalamic arcuate nucleus regulate glucose metabolism and energy homeostasis

This study identifies GHR-expressing neurons in the hypothalamic arcuate nucleus that regulate glucose metabolism and energy homeostasis through GH activation.

Sex hormones underlying 17a-Estradiol effects on neuroinflammation

This study shows 17a-Estradiol reduces neuroinflammation in male mice but not females, with effects mediated by gonadal hormones and region-specific brain changes.